HighVista Strategies LLC

CIK 0001335325 · Q1 2026

13F Equity AUM

$362.2M

-6.7% QoQ

Positions

156

+11 QoQ

AUM Rank

#5,265

Top 42%

Skill Alpha (FF)

-0.4%/yr^ns

No Clear Edge

Rank #2,777 · Top 34%

vs S&P -4.4%/yr (unadj.)

Quarters Tracked

~13 years

Portfolio Concentration

Top 5: 18.4%Top 10: 27.2%Top 20: 39.9%

DBC8.4%

ABVX3.5%

PRAX2.3%

COGT2.1%

SYRE2.0%

PCVX2.0%

RVMD1.9%

TERN1.7%

GPCR1.6%

NUVL1.6%

Others (146)72.8%

HHI (Herfindahl-Hirschman Index) measures portfolio concentration. Low (<1500) = diversified, Moderate (1500-2500), High (>2500) = concentrated bets.

Sector Allocation

Healthcare66.8%

Financial Services10.8%

Technology9.0%

Industrials4.9%

Consumer Cyclical2.6%

Other6.0%

Portfolio weight by GICS sector based on latest 13F filing. Sectors below 2% are grouped as “Other.”

Position Sizing

Positions: 156Median: 0.40%Avg: 0.64%

0–0.5%

95(27.7%)

0.5–1%

36(27.3%)

1–3%

23(33.1%)

3–5%

1(3.5%)

5%+

1(8.4%)

Count of positions per weight bucket — (%) = combined portfolio weight

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Portfolio Overlap

Shared: 156Unique: 0vs 20 funds

2.1%Low

156

Fund positions

7,299

Consensus CUSIPs

Jaccard similarity of this fund’s portfolio vs the consensus of top 20 funds by AUM. Low (<15%) = contrarian, Moderate (15-40%), High (>40%) = follows the crowd.

Most Similar Funds

Top 9 benchmark funds with highest portfolio overlap (Jaccard similarity)

MORGAN STANLEY

2.9%

BlackRock, Inc.

3.9%

BANK OF AMERICA CORP /DE/

3.1%

GEODE CAPITAL MANAGEMENT, LLC

4.2%

STATE STREET CORP

4.2%

FMR LLC

JPMORGAN CHASE & CO

2.8%

VANGUARD CAPITAL MANAGEMENT LLC

3.9%

VANGUARD PORTFOLIO MANAGEMENT LLC

4.6%

Jaccard similarity per fund: shared CUSIPs / (fund A + fund B − shared). Higher values indicate more similar portfolios.

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Position Changes This Quarter

New35Increased46Decreased71Exited24

New Positions

ORKA1.1%

+79K

MLTX1.0%

+194K

DFTX1.0%

+186K

NRIX1.0%

+227K

IVA0.9%

+616K

ERAS0.8%

+181K

XENE0.8%

+49K

VERA0.8%

+69K

ALMS0.7%

+113K

EYPT0.7%

+183K

Increased

PALI1.0%

+719K(+55%)

DYN0.9%

+123K(+207%)

AMLX1.4%

+113K(+47%)

OCUL1.0%

+98K(+28%)

TYRA1.4%

+96K(+274%)

CTMX0.4%

+94K(+49%)

ALKS0.7%

+47K(+177%)

ABVX3.5%

+41K(+57%)

CORZ0.4%

+40K(+63%)

TCE20.8%

+38K(+73%)

Decreased

VRDN0.7%

-238,243(-64%)

BBOT0.2%

-151,076(-66%)

COGT2.1%

-139,616(-41%)

CMPS0.6%

-134,573(-27%)

OLMA0.5%

-123,888(-51%)

RLAY1.2%

-123,198(-23%)

EWTX0.8%

-79,206(-46%)

MLYS0.3%

-77,766(-62%)

MAZE0.8%

-70,503(-41%)

GPCR1.6%

-69,092(-36%)

Exited

-22,928

-75,002

-147,662

-150,776

-40,020

-78,682

-2,482

-7,727

-245,532

-2,269

Quarter-over-quarter changes compared to prior 13F filing. New = first appearance; Exited = no longer held.

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Holdings

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